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The Effect of Ketapang Leaf Extracts (Terminalia catappa L.) on the Cholesterol Levels of Male Mice (Mus musculus L.) Hypercholesterolmia
( Vol-4,Issue-7,July 2017 )
Author(s):

Joko Waluyo, Dwi Wahyuni

Keywords:

Cholesterol, Hypercholesterolemia, Ketapang Leaf Extracts, Male Mice.

Abstract:

Cholesterol is a useful substance for the body to regulate chemical processes such as building cell membranes, producing vitamin D, and forming steroid hormones. Hyper-cholesterol is a condition where cholesterol levels increase over the normal range (>200 mg/dL). One of the herbs which can be used as a cholesterol-lowering substance is Ketapang leaf. The leaf has several compounds which function as antioxidants. Based on Phytochemical test, this leaf contains flavonoid, saponin, tritepen, diterpen, phenolic, and tannin. Those compounds function to inhibit cell damage. This study was aimed to determine the effect of Ketapang leaf extracts (Terminalia catapa L.) to decrease cholesterol levels of hypercholesterolemia of male mice (Mus musculus) which are induced with lard. The study employed experimental design involving 25 male mice, aged at 2 monthsold and weighing 20-30 grams. These mice were divided into 5 groups, comprising of treatment 1 (2 mg/ 20 grams of weight), treatment 2 (4 mg/ 20 grams of weight), treatment 3 (8mg/ 20 grams of weight), positive control (simvastatin 0,26 mg/kg of weight), and negative control (CMC Na 1%). The extract was given for 14 days with 1% volume of weight. The measurement of blood cholesterol levels was done on day 8 as the preliminary data, day 14 after hypercholesterolemia of male mice, day 21 and day 28 after giving Ketapang leaf extracts. The dosage of Ketapang leaves extracts which was given during the treatments significantly affected (p=0,0043) the average of blood cholesterol levels of male mice. Giving the leaf extracts for two months of treatments was found successful in decreasing blood cholesterol 157,62 ± 17,54; 341,55 ± 12,73; 196 ± 16,32; 196,17 ± 16,93 mg/dL.

ijaers doi crossref DOI:

10.22161/ijaers.4.7.8

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  • Page No: 045-049
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[1] Nugraha, Agung, M. 2014. LDL and HDL levels in the Blood Model of Periodontitis Mice. Journal of Health Library. Vol. 2 (1). Jember: University of Jember.
[2] Sandi, C, Saryono, Rahmawati, D. 2008. Differences Blood Cholesterol Levels On Office Workers And Rough Workers In Majasari Village, Bukateja Purbalingga District The Soedirman Journal Of Nursing. Vol. 3 (3) : 131-137.
[3] Baraas, F. 1993. Preventing Heart By Pressing Cholesterol . Jakarta : Gramedia Utama.
[4] World Health Organization (WHO). 2013. Cardiovascular diseases (CVDs) Fact sheet N0 317. Available from: http://www.who.int/mediacentre/fac-tsheets/-fs317/en/ [15 Maret 2015].
[5] Yani, Muhammad. 2015. Controlling Cholesterol Levels On Hypercholesterolemia. Achievement Sport Journal. Vol. 11 (2). Yogayakarta: University State of Yogyakarta.
[6] Pareira, F. M. M. 2010. The Influence of White Dragon Fruit Juice (Hylocereus undatus H.) on Total Cholesterol Mice (Rattus norvegicus). Thesis. Semarang: University of Sebelas Maret.
[7] Dumalag, Rolito M. 2012. Southeast Asian Ecology of the Indonesian Archipelago . Jakarta: Salemba Kartika.
[8] Rosnani. 2008. Terminalia catappa L. as Alternative In Water Treatment System In Shrimp Pond. Malaysia: Universiti Technology Malaysia.
[9] Parubak, A, S. 2013. Antibacterial Flavonoid Compounds from Akway. Chem Prog. Vol 6 (1).
[10] Suhailah. 2016. Effect of Ketapang Leaf Extract (Terminalia catappa L.) on Network Tolerance to Glucose and Island Diamerhans Diamet (Mus musculus L.) Diabetik. Thesis. Surabaya: Airlangga of University.
[11] Astuti. 2007. Practical Guidelines for Biological Material Analysis. Yogyakarta: University State of Yogyakarta.
[12] Vanessa, Rebecca. 2011. Utilization of Instant Wood Powder Drink (Cinnamomum burmanii BI.) To Lower Total Cholesterol Levels In White Rats (Rattus norvegicus). Thesis. Yogyakarta: University Atma Jaya Yogyakarta.
[13] Rumanti, Rizna. 2011. Effects of Propolis on Total Cholesterol Levels on High Fat Model Mice. Journal of Public Health. Vol. 11 (1) Bandung: University of Kristen Maranatha.
[14] Prior RL. Phytochemicals. 2006. Modern Nutrition in Health and Diseases. USA: Lippincott Williams & Wilkins.
[15] E, Kurniawaty. 2013. The Effect of Granting Jengkol Seed Extract (Pithecellobium lobatum Benth.) to Total Cholesterol Levels in The Blood of Rats Diabetes Induced Alloxan. Biodiversitas. Vol. 7 (4). Lampung: University of Lampung.
[16] Herlina, Eka. 2015. Cassava Flakes Formulation (Manihot esculenta Crantz.) As a Potential Antioxidant Breakfast Substitute. Jurnal Fitofarmaka. Vol. 5 (1). Bogor: University of Pakuan Bogor.
[17] Heryansyah, Teuku. 2013. Influence of Duration of Giving a High Fat Diet to White Lipid Lipid Profile (Rattus Novergicus) Strain Wistar . Jurnal Kedokteran Syiah Kuala. Vol. 13 (3). North Sumatera: Universiti of Syiah Kuala.