Dysnomy and Executive Processing Errors of SARS-COV-2 post-infection

Marco Orsini, Jacqueline F.do Nascimento, Nicolle Nunes, Antonio Marcos da S. Catharino, Marcos R.G. de Freitas, Marco Antônio A. Azizi, Thais de R. Bessa-Guerra, Francisco B. M. Oliveira, Thiago R. Gonçalves, Renata R. T. Castro, Paulo Henrique de Moura, Jacenir R.dos S. Mallet, Adalgiza M.Moreno

SARS-COV2; Dementia; Neurological Complications; COVID-19.

Introduction: The disease SARS-CoV-2, named COVID-19, was officially declared a pandemic by the World Health Organization on March 11th, 2020. SARS-CoV-2 contains a single-stranded, positive-sense RNA genome surrounded by an extracellular membrane containing a series of spike glycoproteins resembling a crown. Neuropsychiatric manifestations are common during viral pandemics but are not effectively addressed. Case Report: We report the case of a man, 42 years old, who after the infection by SARS-COV2, presented dysnomy, cognitive easing and errors in motor processing. Results and Discussion: Studies have shown the neuroinvasive capability of SARS-COV2, resulting in neurological complications. Common neurological symptoms are headache, dizziness, anosmia, dysgeusia, mental confusion, and muscle weakening, progressing toward severe complications like cerebrovascular disease, seizures, muscle pain, and Guillain-Barre syndrome. The patient in the present case, about seven days after the initial infection, began to have difficulties in naming basic objects and "cognitive" slowness in the performance of basic and instrumental activities of daily life, especially those that required mutual tasks and that required concentration. Patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. Neuroinvasive capacities and neuroinflammatory events that may lead to the same short- and long-term neuropathologies that SARS-CoV had shown in human and animal models. The presence of dementia, minimal cognitive impairment and problems with motor planning and execution has been described. Conclusion: A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic.

Received: 05 Dec 2020; Received in revised form: 29 Jan 2021; Accepted: 23 Feb 2021; Available online: 28 Feb 2021

10.22161/ijaers.82.41