Greener One-pot Synthesis of Chromeno Oxazin and Oxazin Quinoline Derivatives and their Antibacterial Activity

( Vol-4,Issue-5,May 2017 ) OPEN ACCESS

V.Sruthi, M.Visalakshi, T.Rambabu, Ch.V.V.Srinivas, Y. Vamsi Kumar, M.Sunitha, S. Paul Douglas


One-pot Synthesis, Biological activity, Chromeno oxazin-5-one derivatives, Oxazino quinoline-2-amine derivatives and Oxazino quinoline derivative.


An efficient green method for the synthesis of oxazino quinoline-2-amine derivatives, oxazino quinoline derivatives and chromeno oxazin-5-one derivatives have been synthesized through cyclization of aromatic aldehyde, ammonium acetate, substituted amides and 8-hydroxy-quinoline or 4-hydroxy coumarin by one-pot condensation method is described. The synthesized compounds are characterized by FT-IR, 1H NMR and MASS spectral techniques and are screened further for biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis using cup plate method and disc diffusion method.

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