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Greener One-pot Synthesis of Chromeno Oxazin and Oxazin Quinoline Derivatives and their Antibacterial Activity

( Vol-4,Issue-5,May 2017 ) OPEN ACCESS
Author(s):

V.Sruthi, M.Visalakshi, T.Rambabu, Ch.V.V.Srinivas, Y. Vamsi Kumar, M.Sunitha, S. Paul Douglas

Keywords:

One-pot Synthesis, Biological activity, Chromeno oxazin-5-one derivatives, Oxazino quinoline-2-amine derivatives and Oxazino quinoline derivative.

Abstract:

An efficient green method for the synthesis of oxazino quinoline-2-amine derivatives, oxazino quinoline derivatives and chromeno oxazin-5-one derivatives have been synthesized through cyclization of aromatic aldehyde, ammonium acetate, substituted amides and 8-hydroxy-quinoline or 4-hydroxy coumarin by one-pot condensation method is described. The synthesized compounds are characterized by FT-IR, 1H NMR and MASS spectral techniques and are screened further for biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis using cup plate method and disc diffusion method.

ijaers doi crossref DOI:

10.22161/ijaers.4.5.23

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