In Vitro inhibition of plasmodium falciparum by substances isolated from antimalarial plants. |
| ( Vol-9,Issue-8,August 2022 ) OPEN ACCESS |
| Author(s): |
Mushtaq Ahmad Bhat, Fairooz Ahmad Khan, Dr. H.C.Kataria |
| Keywords: |
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Neosergeolide, Aspidocarpine, 4-nerolidylcatechol, Jurinea dolomiaea, Alstonia scholaris and Datura stramonium. |
| Abstract: |
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In the present study, a neosergeolide, isolated from the roots of Jurinea dolomiaea Boiss (Asteracae), the indole alkaloid aspidocarpine, isolated from the bark of Alstonia scholaris (Apocynaceae) and 4-nerolidylcatechol, isolated from the seed of Datura stramonium Linn. (Solinaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. These compounds are good for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and provide support to the traditional use of the plants. |
| Article Info: |
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Received: 15 Jul 2022, Received in revised form: 04 Aug 2022, Accepted: 09 Aug 2022, Available online: 13 Aug 2022 |
 DOI:
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Advanced Engineering Research and Science