Innovation of System Biological Approach in Computational Drug Discovery |
( Vol-3,Issue-12,December 2016 ) OPEN ACCESS |
Author(s): |
Srinath Pandey, Ved Kumar Mishra, Swati Dwivedi, Shubhangi Dixit, Raghvendra Raman Mishra, Prashant Ankur Jain |
Keywords: |
Systems Biology, Protein Profiling, Network, Nodes & Edges, Attributes, Annotation etc. |
Abstract: |
Computational methods like classification and network-based algorithms can be used to understand the mode of action and the efficacy of a given compound and to help elucidating the patho-physiology of a disease. In the pharmacological industry there has already been a shift from symptomatic oriented drugs that can relieve the symptoms but not the cause of the disease to pathology-based drugs whose targets are the genes and proteins involved in the etiology of the disease. Drugs targeting the affected pathway have thus the potential to become therapeutic. A network approach to drug design would examine the effect of drugs in the context of a network of relevant protein regulatory metabolic interactions resulting in the development of a drug that would hit multiple targets selected in such a way as to decrease network integrity and so completely disrupt the functioning of the network. The screening of a compound to quickly identify the proteins it interacts with gives us all the necessary tools to identify and repair the deregulated biological pathway causing the disease. |
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Advanced Engineering Research and Science