Study evaluating the ability of Fe-BDC-PEG to carry and release active ingredient 5-fluorouracil

Thu Hanh Pham Thi, Hoai Phuong Nguyen Thi

Metal-organic framework, 5 Fluorouracil, drug carrier, ultrasonic method.

This paper presents the results of 5 fluorouracil carrying-release of iron (III) framework materials with two ligands of 1,4-benzene dicarboxylic acid and polyethylene glycol diacid synthesized by ultrasonic bath method at room temperature. Materials were characterized, and their properties by scanning electron microscopy (SEM) and infrared spectroscopy (FT-IR) techniques showed that the active ingredient was fully adsorbed into the structural framework of the material without changing the shape and size of the material. The evaluation results for the 5-fluorouracil carrying capacity of Fe-BDC-PEG two-ligand Fe-BDC-PEG framework material showed that the drug absorption capacity reached 358.707 mg/g. The slow-release characteristics of the material were also evaluated, indicating that the effective release of the active ingredient came to 94.42% after 7 days, and the maximum after 10 days reached 97.68%. The Fe-BDC-PEG@5-FU drug carrier material system is studied to orient the application of cancer treatment when minimizing side effects based on the slow release of the system.

Received: 15 Jan 2023 Received in revised form: 8 Mar 2023 Accepted: 13 Mar 2023 Available online: 19 Mar 2023

10.22161/ijaers.103.5