Synthesis and biological activity of some heterocyclic compounds contains N-benzylidene heterocycle and beta-lactam moiety

Milad Alizadeh, Naser Foroughifar, Mehran davallo, Mahsa Karimian

Antibacterial activity, Green chemistry , isatin , thiazole , N-benzylidene heterocycle

A number of N-benzylidene heterocycle derivatives have been synthesized and their antibacterial activities tested. The new chemical structures synthesized compounds were verified on the basis of spectral and elemental methods of analyses.the antimicrobial activity of the compounds was done by disc diffusion method We synthesized two different types of compounds, a combination of compounds based on the structure of isatin and other compounds based on the structure of thiazole. Synthesis of thiazole was performed using green chemistry method and a three-step reaction was used in the synthesis of isatin compounds. We used the Stoell-Becker method to synthesize compounds based on the isatin structure. The synthesized product was characterized by its physical properties, melting point, TLC and then subjected to the in vitro antibacterial activities against gram-positive and gram-negative strains of microbes

10.22161/ijaers.5.9.15