Systematic review on the relationship between HIV, Antiretroviral Therapy (ART), hyperglycemia and hypercholesteremia

Edmundo Luís Rodrigues Pereira, Guilherme Alves da Silva, Marília da Silva Duarte, Roberta iris Cavalcante de sousa,Pedro Henrique Aguiar Lobato, Bruno Oliveira Biral, Jadde de Souza Barros, Paloma Félix Gonçalves, Marcela Magno Miranda Bezerra,Gleydson de Azevedo Almeida,Salomão Leal Nava, Mônica Maria de Moraes Lima Ferreira, Gilvandro Ubiracy Valente Filho, Paulo José Carneiro Lédo, Lorena Franco Carneiro Ledo, Ingrid Paola Canto Gomes de Oliveira, Leandro Nazareno Almeida da Silva, Joelma Bello de Barros, Manuele Maria Redig Gonçalves,Jamylle Pedrosa Gomes, Paulo Henrique Martins Santos Da Fonseca, Álvaro Henrique Paes da Cruz Santos, Débora Virgínia Peixoto Montes, Virgínia Márcia Peixoto Montes, Johnny Wesley Bastos Nonato, Juliane Santos da Costa, Leandro Nazareno Almeida da Silva, Juliana Albim Linhares,Jully Jamile Ribeiro dos Reis

HIV infection, Antiretroviral Therapy (ART), metabolic disorders, hyperglycemia, dyslipidemia.

HIV (Human Immunodeficiency Virus) infection continues to be a global public health concern, with millions of people living with the virus around the world, largely due to advances in Antiretroviral Therapy (ART) associated with ostensible prevention campaigns. However, if on the one hand a significant increase in the survival of patients with HIV is observed with the use of ART, on the other hand several studies warn of the adverse effects of prolonged use of ART on the metabolic system, particularly in the induction of a persistent hyperglycemic and hypercholesterolemic state, disorders that contribute to the overall reduction in survival due to the emergence of complications related to prolonged hyperglycemia and dyslipidemia, which motivated the present systematic review on the topic.

Received: 26 Feb 2025, Receive in revised form: 28 Mar 2025, Accepted: 07 Apr 2025, Available online: 13 Apr 2025

10.22161/ijaers.124.5