The Role of the Microbiome in Antibiotic Resistance and Infection Control

Djosci Coêlho de Sá Júnior, Ricardo Baroni Vieira, Ana Claudia Borges Braga, Hellen Kristina Magalhães Brito, Giovanna Uchôa de Souza Cruz, Guilherme de Almeida Leite Furtado, Victoria Carolinne Oliveira Silva, Karina Meira de Miranda, Felipe Machado Dourado Bastos, Luiza Valesca Barros Teixeira, Hugo Soares Lira Azevedo, Laura Maria Lopes Sá Luz Costa, Isabela Godoy Santos, Ana Clara Souza Barreto da Cunha, Lucca Pazini Meneghel Paiva, Ana Luiza de Pellegrini Maciel Zanina, Karollyne Nunes Marinho

Microbiome, Antibiotic Resistance, Infection Control, Therapeutic Strategies, Microbial Communities

This review explores the critical role of the microbiome in modulating antibiotic resistance and its implications for infection control. By synthesizing recent research, we highlight how microbial communities influence the emergence and dissemination of antibiotic resistance genes and their impact on host health and disease outcomes. The interplay between the microbiome and antibiotics suggests a need for novel strategies to manage resistance, emphasizing microbiome-preserving approaches. Our findings underscore the potential of leveraging microbiome insights to develop more effective infection control practices and antibiotic use policies, aiming to mitigate the global challenge of antibiotic resistance. Future research directions are suggested to further understand the microbiome's mechanisms in resistance and identify therapeutic opportunities for enhancing human health.

Received: 05 Dec 2023, Receive in revised form: 15 Jan 2024, Accepted: 28 Jan 2024, Available online: 11 Feb 2024

10.22161/ijaers.112.2