The Use of Artificial Scaffolds and Biofilms in Antibiotic Research

Djosci Coêlho de Sá Júnior, Ricardo Baroni Vieira, Giovanna Uchôa de Souza Cruz, Bruna Postal Oliveira, Isadora Ferreira Batista, Kamilla Dutra Silva, Felipe Machado Dourado Bastos, Karina Meira de Miranda, Claudionor Antonio de Oliveira Amorim Neto, Isabela Godoy Santos, Laura Maria Lopes Sá Luz Costa, Thiago Brilhante Pereira Labre, Gabriela Fernandes Ribeiro, Laura Geovanna da Costa Reis Carvalho, Lucas Torres Tavares, Maria Eduarda Santos Albuquerque, Sarah Lorrayne Gomes Pereira Cardoso

Artificial Scaffolds, Biofilms, Antibiotic Research, Bacterial Behavior, Interdisciplinary Collaboration

This literature review explores the utilization of artificial scaffolds and biofilms in advancing antibiotic research. It highlights the critical role these innovative models play in mimicking the complex environments of natural biofilms, crucial in bacterial survival, antibiotic resistance, and infection persistence. By offering insights into bacterial behavior, interaction, and resistance development under conditions closely resembling their natural habitats, artificial scaffolds and biofilms enable more effective study and development of strategies to combat antibiotic resistance. The paper underscores the necessity for continued innovation and interdisciplinary collaboration to refine these models, enhancing their clinical relevance and broadening their application to various bacterial species and infection contexts.

Received: 03 Dec 2023, Receive in revised form: 11 Jan 2024, Accepted: 29 Jan 2024, Available online: 11 Feb 2024

10.22161/ijaers.112.4