Study of the neutralization of cell multiplication, in vitro, with Botulinum Neurotoxin Type A

Adriana Novaes Rodrigues, Andressa Duarte

Anti-cancer enzymes; Bacterial toxins; Botulinum toxin type A; Apoptosis.

Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of cutaneous carcinogenesis is not fully understood. However, several studies have been carried out to better explain the mechanisms that lead to malignancy. Methods: We tested in vitro the neutralization of non-melamoma carcinoma cell replication with botulinum toxin. Results: There was no significance in cell inhibition. Conclusion: Although our results have not been promising, further research with botulinum toxin should be encouraged to provide additional data on its effects on skin lesions, as with current evidence it is possible to correctly plan clinical trials aimed at testing its action on the skin. non-melanoma skin cancer

Received: 14 Jul 2021, Received in revised form: 12 Aug 2021, Accepted: 20 Aug 2021, Available online: 26 Aug 2021

10.22161/ijaers.88.43